GLP-1 & metabolic
5-Amino 1MQ Price Comparison
Also referred to as: 5-Amino-1-Methylquinolinium (5-Amino-1MQ) · NNMT Inhibitor
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For in-vitro laboratory research only
5-Amino 1MQ is listed here as a research material. It is not for human or veterinary consumption, and nothing on this page is medical advice or dosing guidance. PeptideCompare is paid by flat supplier fees — never by sales commission or referral — so a price ranks by its number, not by who pays. We do not sell, test or verify any product, and quality or CoA labels are suppliers’ own claims. Always check the final price, documentation and legality with the supplier yourself.
Research profile
About 5-Amino 1MQ in the lab
5-Amino-1MQ is not a peptide but a small quinolinium compound. It appears in preclinical work on nicotinamide N-methyltransferase (NNMT), an enzyme that is highly expressed in adipose tissue. Most published data come from cultured fat cells and rodent models.
Proposed mechanism
Blocks NNMT, which normally methylates nicotinamide. Less NNMT activity is thought to preserve the cellular nicotinamide pool available for NAD+ salvage and to shift methyl-donor balance.
Structure note
Small molecule NNMT enzyme inhibitor.
Typical research themes
- NNMT enzyme inhibition
- NAD+ salvage pathway
- Adipocyte metabolism models
Key references
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. · Biochemical pharmacology (2018)
- Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. · Biochemical pharmacology (2019)
- NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. · Nature chemical biology (2013)
- Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. · Trends in endocrinology and metabolism: TEM (2017)
This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.
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