Skin & cellular longevity
FOX04-DRI Price Comparison
Also referred to as: FOXO4 DRI · FOXO4-DRI peptide · FOXO4-DRI (p53-interaction inhibitor) · FOXO4‑DRI
UK supplier comparison
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For in-vitro laboratory research only
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Research profile
About FOX04-DRI in the lab
FOXO4-DRI is a modified peptide built from D-amino acids in reverse order to resist breakdown. A 2017 mouse study reported that it cleared senescent cells, making it a reference compound in senolytic research.
Proposed mechanism
Disrupts the interaction between FOXO4 and p53 in senescent cells, releasing p53 from the nucleus so it can trigger apoptosis in those cells specifically.
Structure note
D‑retro‑inverso cell‑penetrating peptide (FOXO4 CR3‑derived) (~34 amino acids (D‑retro‑inverso)).
Typical research themes
- Senolytics
- FOXO4–p53 interaction
- Retro-inverso peptides
This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.
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