GHK-Cu Price Comparison

Research profile

About GHK-Cu in the lab

GHK was first isolated from human plasma and binds copper with high affinity. It is widely referenced in in-vitro studies on fibroblast behaviour, extracellular-matrix remodelling and gene-expression profiling.

Proposed mechanism

Forms a high-affinity complex with copper(II). In fibroblast and wound models it is associated with changes in collagen and glycosaminoglycan synthesis, metalloproteinase activity and broad gene-expression shifts.

Structure note

Gly-His-Lys tripeptide chelating a Cu(II) ion. The free peptide (GHK) is ≈ 340.4 g/mol.

Amino-acid sequence (one-letter)

GHK

Typical research themes

• Fibroblast culture
• Extracellular matrix
• Metal-ion chelation chemistry
• Gene-expression profiling

Key references

1. Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells. · Nature (1980)
2. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. · FEBS letters (1988)
3. Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. · Life sciences (1992)
4. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. · Life sciences (2000)

This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.