Skin & cellular longevity
MOTS-c Price Comparison
Also referred to as: Mitochondrial ORF of the 12S rRNA type-c · Mitochondrial Open Reading Frame of the 12S rRNA-c (C) · Mitochondrial Open Reading Frame of the 12S rRNA-c · Mitochondrial-Derived Peptide
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For in-vitro laboratory research only
MOTS-c is listed here as a research material. It is not for human or veterinary consumption, and nothing on this page is medical advice or dosing guidance. PeptideCompare is paid by flat supplier fees — never by sales commission or referral — so a price ranks by its number, not by who pays. We do not sell, test or verify any product, and quality or CoA labels are suppliers’ own claims. Always check the final price, documentation and legality with the supplier yourself.
Research profile
About MOTS-c in the lab
A mitochondrial-derived peptide. In cell and animal models it has been studied in connection with AMPK signalling and metabolic homeostasis.
Proposed mechanism
Reported to inhibit the folate cycle and de novo purine synthesis, raising AICAR levels and activating AMPK; under stress it can move to the nucleus and influence stress-response gene expression.
Structure note
16-residue peptide encoded in the mitochondrial 12S rRNA gene (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg).
Amino-acid sequence (one-letter)
MRWQEMGYIFYPRKLR
Typical research themes
- AMPK signalling
- Mitochondrial-derived peptides
- Cell-stress models
Key references
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. · Cell metabolism (2015)
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. · Nature communications (2021)
- Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance. · Pediatric diabetes (2018)
This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.
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