Endocrine & reproductive
Kisspeptin Price Comparison
Also referred to as: Kisspeptin (KISS1-Derived Neuropeptide) · KP-10 · KP-54 · Metastin · KISS1 Gene Product
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For in-vitro laboratory research only
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Research profile
About Kisspeptin in the lab
Kisspeptins are peptides encoded by the KISS1 gene; kisspeptin-10 is the shortest active fragment. They are key upstream regulators of puberty and fertility and are studied in neuroendocrine research.
Proposed mechanism
Binds KISS1R (GPR54) on GnRH neurons, depolarising them and triggering GnRH release, which in turn drives pituitary LH and FSH secretion.
Structure note
Neuropeptide family (RFamide) (10-54 amino acids).
Amino-acid sequence (one-letter)
??NWNSFGLRF?
Typical research themes
- KISS1R signalling
- GnRH neuron activity
- Neuroendocrine control
Key references
- Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. · Nature (2001)
- The GPR54 gene as a regulator of puberty. · The New England journal of medicine (2003)
- Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. · Proceedings of the National Academy of Sciences of the United States of America (2003)
- Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. · Proceedings of the National Academy of Sciences of the United States of America (2005)
This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.
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