Neuropeptides & sleep
PE-22-28 Price Comparison
Also referred to as: Spadin Analogue PE-22-28 · Mini-Spadin · TREK-1 Channel Blocker
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For in-vitro laboratory research only
PE-22-28 is listed here as a research material. It is not for human or veterinary consumption, and nothing on this page is medical advice or dosing guidance. PeptideCompare is paid by flat supplier fees — never by sales commission or referral — so a price ranks by its number, not by who pays. We do not sell, test or verify any product, and quality or CoA labels are suppliers’ own claims. Always check the final price, documentation and legality with the supplier yourself.
Research profile
About PE-22-28 in the lab
PE-22-28 is a shortened, optimised analogue of spadin, a peptide from the sortilin propeptide. It is studied in rodent models of depression-like behaviour and neurogenesis because of its action on TREK-1 channels.
Proposed mechanism
Blocks TREK-1 two-pore-domain potassium channels, increasing neuronal excitability in serotonergic circuits; it is reported to be more stable than spadin.
Structure note
Linear heptapeptide (7 amino acids).
Amino-acid sequence (one-letter)
GVSWGL?
Typical research themes
- TREK-1 channels
- Serotonergic signalling
- Neurogenesis models
This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.
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