Growth hormone axis
Ipamorelin Price Comparison
Also referred to as: NNC 26-0161 · Ipamorelin (Growth Hormone-Releasing Pentapeptide) · Growth Hormone Secretagogue
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For in-vitro laboratory research only
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Research profile
About Ipamorelin in the lab
A synthetic ligand for the growth-hormone secretagogue receptor (GHS-R1a). In vitro it is used to examine receptor selectivity relative to other secretagogues.
Proposed mechanism
Activates GHS-R1a on pituitary somatotrophs to release GH. Compared with earlier GHRPs it shows little effect on ACTH, cortisol or prolactin in animal studies, which makes it a selectivity reference.
Structure note
Aib-His-D-2Nal-D-Phe-Lys-NH2, a pentapeptide featuring non-proteinogenic residues.
Typical research themes
- GHS-R1a binding
- Receptor selectivity profiling
- Pituitary cell culture
Key references
- A receptor in pituitary and hypothalamus that functions in growth hormone release. · Science (New York, N.Y.) (1996)
- Ghrelin is a growth-hormone-releasing acylated peptide from stomach. · Nature (1999)
- Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. · Endocrine reviews (2004)
This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.
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