Growth hormone axis
MGF Price Comparison
Also referred to as: Mechano Growth Factor (IGF-1Ec) · Mechano Growth Factor · IGF-1Ec · MGF-24aa-E
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For in-vitro laboratory research only
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Research profile
About MGF in the lab
MGF (IGF-1Ec in humans) comes from alternative splicing of the IGF-1 gene and has a unique C-terminal E-peptide. Research focuses on that E-peptide and its role in muscle-stem-cell activation after mechanical stress.
Proposed mechanism
The E-domain peptide is reported to activate muscle satellite cells and MAPK/ERK signalling, partly independently of the IGF-1 receptor; findings vary between studies.
Structure note
IGF-1Ec splice variant C-terminal peptide (24 amino acids).
Typical research themes
- IGF-1 splice variants
- Satellite cells
- Mechanotransduction
Key references
- Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation. · The Journal of physiology (1999)
- Age-related loss of skeletal muscle function and the inability to express the autocrine form of insulin-like growth factor-1 (MGF) in response to mechanical overload. · FEBS letters (2001)
- Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. · The Journal of physiology (2003)
- Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. · Endocrinology (2010)
This profile is a short, general summary of publicly discussed science. It is not exhaustive, not peer-reviewed by PeptideCompare, and is not medical advice. PeptideCompare provides no dosing, protocol or usage guidance — nothing here is for human or veterinary use.
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